Alright, bear with me as I go through the tedious checklist. 
Updated with Application Manager to latest version: 11.0.2
Windows Vista 64-bit Service Pack 2
Simply crashes while trying to open. No new programs have been installed since I last ran AfterEffects, however I have applied updates to my adobe products.
I'll get the splash screen, and then near abot the end of the "cleaning up" portion, I get a Windows error saying that "Adobe After Effects CS6 has stopped working".
Here is the latest trace from the Event Viewer in the Computer Management console:
Log Name: Application
Source: Application Error
Date: 5/14/2013 8:13:13 PM
Event ID: 1000
Task Category: (100)
Level: Error
Keywords: Classic
User: N/A
Computer: Necrofear
Description:
Faulting application AfterFX.exe, version 11.0.2.12, time stamp 0x505998cf, faulting module ntdll.dll, version 6.0.6002.18541, time stamp 0x4ec3e855, exception code 0xc0000374, fault offset 0x00000000000acb17, process id 0x173c, application start time 0x01ce511a1d0a36c6.
Event Xml:
<Event xmlns="http://schemas.microsoft.com/win/2004/08/events/event">
<System>
<Provider Name="Application Error" />
<EventID Qualifiers="0">1000</EventID>
<Level>2</Level>
<Task>100</Task>
<Keywords>0x80000000000000</Keywords>
<TimeCreated SystemTime="2013-05-15T03:13:13.000Z" />
<EventRecordID>35174</EventRecordID>
<Channel>Application</Channel>
<Computer>Necrofear</Computer>
<Security />
</System>
<EventData>
<Data>AfterFX.exe</Data>
<Data>11.0.2.12</Data>
<Data>505998cf</Data>
<Data>ntdll.dll</Data>
<Data>6.0.6002.18541</Data>
<Data>4ec3e855</Data>
<Data>c0000374</Data>
<Data>00000000000acb17</Data>
<Data>173c</Data>
<Data>01ce511a1d0a36c6</Data>
</EventData>
</Event>
I've attempted a reinstall, with clearing preferences. That hasn't helped one bit. To be honest, I don't use it often either, I just kinda found a need for it now, probably haven't used it since.... mid-March? Yes, I have Quicktime installed (7.7.3), and regardless if I close down all of my programs, it still occurs.